Adverse health outcomes among long-term survivors of childhood, teenage and young adult cancer

[摘要] Survivors of childhood, teenage and young adult cancer are at increased risk of developing adverse health outcomes. This thesis aims to address the gaps in knowledge regarding the most severe adverse health outcomes. The Teenage and Young Adult Cancer Survivor Study (TYACSS) provides 200,945 survivors of cancer diagnosed aged 15-39 years. The PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) provides 69,460 survivors of cancer diagnosed aged <20 years. Within the TYACSS cohort 1) cancer survivors had increased risk of developing subsequent primary neoplasms, particularly in previously irradiated sites; 2) cancer survivors who likely received cranial irradiation had increased risk of a cerebrovascular event; and 3) central nervous system tumour survivors experienced premature mortality due to neoplastic and nonneoplastic causes. Within the PanCareSurFup cohort 1) the excess number of subsequent softtissue sarcoma was low, except leiomyosarcoma after retinoblastoma; and 2) the excess number of subsequent breast cancers remained elevated beyond 40 years of age among survivors of Hodgkin lymphoma, Wilms tumour and sarcoma. This thesis focuses on the most severe adverse health outcomes among childhood, teenage and young adult cancer survivors and provides evidence for developing clinical follow-up guidelines aimed at reducing such adverse health outcomes.

[发布机构] University:University of Birmingham;Department:Institute of Applied Health Research

[关键词] R Medicine;RC Internal medicine;RC0254 Neoplasms. Tumors. Oncology (including Cancer)