The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis

[摘要] Non Cystic Fibrosis bronchiectasis is characterised by perpetual neutrophilic inflammation in the lungs.The ongoing vicious cycle of bronchiectasis leads to further damage to already damaged airways and is a culmination of repeated infection, inflammation and failure of the host response to maintain sterility of the airway, despite a sophisticated innate and adaptive immune system. Pseudomonas aeruginosa commonly colonises the lungs of patients with bronchiectasis.I hypothesised that the concept of inhibitory antibodies in the serum may be a feature of Pseudomonas aeruginosa colonisation through a specific interaction between the host adaptive immune system and strain specific features. Here I have identified a mechanism where some patients colonised with Pseudomonas aeruginosa produce IgG2 antibodies specifically against the O antigen of bacterial LPS, which rather than promote complement-mediated killing actually inhibits it.

[发布机构] University:University of Birmingham;Department:Institute of Clinical Sciences

[关键词] R Medicine;R Medicine (General)