Design of photo-switchable self-assembled monolayers for the study of protein-receptor interactions

[摘要] Nano-biotechnology combines recent advances in nanotechnology with biology. It is a relatively new discipline and full of promise. One such promise is the elucidation of complex bio-molecular reactions and interactions, the elucidation of which requires the development of reliable in-vitro models. Such models could be developed through the use of self-assembled monolayer’s (SAMs). Research into this competitive field has already started and there is currently a call to develop SAMs which present specific bio-molecules in a switchable fashion; switchable SAMs can have their surface properties switched between two states, i.e. they can be switched ‘on’ or ‘off’. Such switch-ability would help such models mimic the real time changes of the bodies’ bio-chemistry and is a vital development. This thesis addresses this current research need, through the employment of azobenzene based SAMs. Currently the switch-ability (isomerisation) of numerous azobenzene SAMs has been shown to be hindered by a lack of inter-surfactant space. This hindrance to isomerisation is addressed in Chapter 4.While Chapter 5 explores the design of an azobenzene based photo-switchable SAM, for use as in-vitro model for the study of bio-molecular interactions. The two chapters are not directly related and future work would aim to bring the findings together.

[发布机构] University:University of Birmingham;Department:School of Chemistry

[关键词] Q Science;Q Science (General)