Application and development of high-density functional near infrared spectroscopy for traumatic brain injury

[摘要] Functional near infrared spectroscopy (fNIRS) is a non-ionising, non-invasive, portable and relatively inexpensive method of measuring cerebral oxygen saturation. One potential application of fNIRS is as a monitoring modality for patients with traumatic brain injury (TBI) in order to guide therapy in both the emergency and clinical settings. However, despite its potential, uncertainty in signal origins (superficial contamination) has meant that current literature describes fNIRS as a 'work in progress' and as not currently suitable as a standalone technique to replace x-ray computerised tomography or invasive intracranial pressure monitors for TBI care. In order to address such limitations, the work within this thesis examined the viability of existing fNIRS devices, explored the utility of atlas-based reconstruction algorithms, and a prototype, high-density near infrared spectroscopy probe to improve the quantitative assessment of cerebral haemodynamics (including oxygen saturation) for use in TBI care. The presented data demonstrates that a high-density probe and Atlas-based reconstruction method is capable of more accurately mapping cerebral oxygen saturation than conventional fNIRS.

[发布机构] University:University of Birmingham;Department:School of Chemistry

[关键词] Q Science;QA Mathematics;QA75 Electronic computers. Computer science