An investigation of granulated sugar dressing in the management of sloughy, necrotic and infected exuding wounds

[摘要] Aim: Investigated the use of granulated sugar in the management of sloughy, necrotic and infected exuding wounds. Method: The investigation followed the Medical Research Council (MRC, 2007) framework for investigation of complex interventions.Pre-clinical: The study was registered with MHRA, followed by development and design of the mode of sugar delivery to patient use.Evidence review: A systematic review and meta-analysis concluded that there was no existing good quality evidence to support the routine use of sugar dressings. Phase I: Laboratory studies found that all three sugars showed relatively equal activity against all the bacteria tested although Demerara sugar was slightly less active.Phase II:A feasibility study of 22 patients concluded that both insulin and non-insulin treated diabetic patients can be treated with sugar dressing without affecting their blood sugar levels.Phase III: A randomised controlled trial failed to recruit the intended numbers and final analysis was carried out on 22 patients randomised to sugar and 19 randomised to usual care. 19 (86%) achieved debridement at 4 weeks in the sugar group compared to 6 (32%) standard care group (Fisher’s exact test: p<0.001).Overall conclusion: Sugar has an effect on micro-organisms and can be used in modern hospitals and community settings.

[发布机构] University:University of Birmingham;Department:School of Health and Population Sciences

[关键词] R Medicine;R Medicine (General)