Two case studies of SPH modelling in biological system: large intestine and deep vein valves

[摘要] Computational Fluid Dynamics (CFD) techniques has proven its adaptiveness and mutuality in various application for diversified fields. At the moment, the investigation of physical mechanics developed by CFD in physiological transportation has arisen great attention. This thesis aims at deepening the insight into the interactive mechanism between the periodic deformable human conduits and the conveyed fluid content. To start with a coupled method consists of Smoothed Particle Hydrodynamics (SPH) method and Coarse-Grained Molecular Dynamics (CGMD) I Mass-spring modelling (MSM) is adopted as it has proven its potentials in dealing with the transportation inside the deformable solid boundaries. The fluid part is simply simulated by the SPH method while the soft solid boundaries are mimicked by another one to yield the optimal utility of the coupled method. Our models developed for Gastric Intestine (GI) system are first validated by comparisons with PET experimental outcomes and are applied to the practical usage. Quantitative analysis is made among simulations to illustrate the mixing and transportation of food propelled by the muscle peristalsis. Then the method is further extended into the study of the venous system and the results indicate a good interpretation of the pathological study of the valve dysfunction and the venous development.

[发布机构] University:University of Birmingham;Department:School of Chemical Engineering

[关键词] T Technology;TP Chemical technology