An investigation into the role of various food components on the solubility and dissolution of propylthiouracil and penicillin v in paediatrics and An investigation into the role of oestrogen receptor β in medullary thyroid cancer

[摘要] Project 1: Oral drug absorption, and therefore efficacy, can be affected by food-drug interactions. Food-drug effect clinical studies are rarely carried out in children, despite sometimes having different food-drug effects to adults. The aim was to see which food components affect the absorption of propylthiouracil and penicillin V. Propylthiouracil is best administered to children with more acidic foods, such as apple sauce or fruit juice, while more neutral foods high in fat, calcium and protein, for example milk and yoghurt, should be avoided, due to negative effects on absorption. Conversely, penicillin V should be delivered with neutral foods, but not acidic foods. Project 2: Medullary thyroid cancer (MTC) is a rare, aggressive tumour type. Hereditary MTC has recently been associated with inactivating mutations in oestrogen receptor β (ERβ). When functional ERβ is lost through mutation, anti-proliferative regulation may be lost, potentially resulting in tumourigenesis. The aims were to achieve significant ERβ knockdown, and see whether knockdown affects Ret, cyclin D1 and IGF-1R expression (other oestrogen-responsive genes involved in cell proliferation). RNA levels of Ret and cyclin D1 were statistically unchanged with significant ERβ knockdown, or oestrogen treatment. However, MTC may arise due to increased IGF-1R expression when functional ERβ expression is reduced.

[发布机构] University:University of Birmingham;Department:School of Clinical and Experimental Medicine

[关键词] R Medicine;R Medicine (General)