Design and development of emulsions for encapsulation and molecular delivery applications

[摘要] The design and development of smart colloidal structures intended for molecular encapsulation and delivery of functional molecules is an area of intense academic and industrial interest. A major part of this area is focussed on stimulating molecular release using an external stimulus such as pH or temperature. Whilst controlled delivery technologies are a mainstay of the pharmaceutical industry, aligned industries that utilise formulation to deliver functional molecules are also targets for encapsulation technology implementation. This can be a key driver for ameliorating competition from generic manufacturers, as any resulting can patent protection can be applied to the formulation. Current approaches in colloidal encapsulation and molecular delivery have mainly been concerned with encasing and subsequent release of a single functional molecule. However, there is interest in being able to structure two or more functional molecules within a “simple” emulsion microstructure for dual release over different timescales. Within colloid science, emulsions offer significant potential in this area due to the potential for compartmentalisation within the multiphase components. This thesis focuses on the design and development of Pickering emulsions structured with two actives segregated within their microstructure. This was achieved through the fabrication of colloidal Pickering particles designed with the dual purpose of being both emulsion stabilisers and molecular carriers. The work ultimately combines colloid structure design, development and characterisation with molecular encapsulation and release studies.

[发布机构] University:University of Birmingham;Department:School of Chemical Engineering

[关键词] T Technology;TP Chemical technology