Investigation of Uniform Biomaterial-Based Microspheres With Precisely Controlled Size and Size Distribution for Development of Advanced Drug Delivery Systems

[摘要] Uniform chitosan MS (CMS) were employed for precisely controlled delivery of acidic drug, where colon-specific delivery could be realized without any additive polymers or toxic process. For strong acidic drug, the smaller the CMS, the more drugs could be contained until the colonic site hence the better candidate for colon-specific delivery. Weak acidic drug preferred the larger CMS due to the smaller amount of release at the gastric fluid.

[关键词] Engineering, Materials Science