Successful Reversal of Diabetes by Single Donor Isologous Islet Transplantation in a Mouse Model

[摘要] A method for isolating mouse islets which consistently gives a high yield with good purity is described. Using a bovine serum albumin gradient, the mean yield of islets per pancreas is 425 (SEM ± 15) with a consistent purity of over 90%. Single donor to single recipient of islets transplanted under the renal capsule restores normoglycemia in the diabetic recipients within 2 to 5 days of transplantation.

[发布日期] 1997-07-01

[关键词] Diabetes;Islet;Transplantation;Mouse