The Role of Mucosal Immunity: An Update

[摘要] There is considerable evidence that the mucosa associated lymphoid tissues (MALT) of the body play an active part in triggering off and conducting the immune system's response to both viral and bacterial pathogens. Effectors are capable of intercepting the micro-organisms and rendering them harmless before they penetrate through the mucous membranes, or of expelling and inactivating them after they have penetrated. The system is consequently useful both in the prevention of infection and in the humoral or cellulo-mediated immune response. These operations, whose principal protagonists are Immunoglobulins A and dendritic cells, are made possible by the high degree of functional interconnection which binds the effectors of the system and the anatomical structures located in the mucosae. The data provided in literature consequently infer that appropriate stimulation of mucosal immunity, which takes into account the new acquisitions in the field of immunology, can enable oral vaccination to overcome the obstacles encountered up till now in terms of insufficient protection against diseases.

[发布日期] 2005-01-01

[关键词] mucosal immunity;oral vaccines;IgA;dendritic cells