The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

[摘要] Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.

[关键词] Breast cancer;Race;Ethnicity;Disparities;Clinical outcomes;Socioeconomic status;CDK4/6 inhibitors;PARP inhibitors;BRCA mutations;Targeted therapy;Precision oncology