Characterization of sunscreen cream containing benzophenone-3,3',4,4'-tetracarboxylate dianhydride

[摘要] The purpose of this research was to evaluate in-vitro sunscreen activity of a cream formulation containing benzophenone-3,3',4,4'-tetracarboxylate dianhydride (BTDA). Sunscreen is used to protect skin from the adverse effects of ultraviolet (UV)A (320-400 nm) and UVB (290-320 nm) radiation. The most common chemical sunscreen is derivatives of benzophenone. The potency of benzophenone-3,3',4,4'-tetracarboxylate dianhydride for sun protection was evaluated using in-vitro spectrophotometric technique. Several cream formulation containing 5% (F1), 6% (F2), and 7% (F3) BTDA were designed. These cream were subjected to physical characteristic such as, organoleptic, viscosity, homogeneity, pH, spreadability, adhesivity, and stability (tuliskan satuan -bila ada). The sun protection factors (SPF) were analyzed by spectrophotometry using samples irradiated with UV in B region. All cream formulations showed good physical characteristics. The formulation of sunscreen cream containing BTDA meets the requirements of physical properties. SPF values of BTDA, F1, F2, and F3 were 6.40±0.21; 0.27±0.03; 0.87±0.01; and 0.56±0.00, respectively. All cream formulations of sunscreen cream containing BTDA meets the requirements of physical properties with satisfactory characteristics, but does not indicate any sun protection activities.

[发布机构] Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh PO. Box 202, Purwokerto; 53182, Indonesia^1

[效力级别] 自然科学

[关键词] Adhesivity;Adverse effect;Benzophenone-3;Physical characteristics;Spreadability;Sun protection;Sun protection factor;Ultra-violet