Non-invasive blood glucose monitoring with Raman spectroscopy: prospects for device miniaturization

[摘要] The number of patients with diabetes has reached over 350 million, and still continues to increase. The need for regular blood glucose monitoring sparks the interest in the development of modern detection technologies. One of those methods, which allows for noninvasive measurements, is Raman spectroscopy. The ability of infrared light to penetrate deep into tissues allows for obtaining measurements through the skin without its perforation. This paper presents the limitations and possibilities of non-invasive blood glucose monitoring with Raman spectroscopy. Especially focusing on the possibilities for device miniaturization. Such device incorporates a Raman spectrometer, a fiber-optical probe, and a computing device (microcontroller, smartphone, etc.) which calculates the glucose concentration using specialized algorithms. Simplification of device design, as well as turbidity correction technique and a new proposed method of synchronized detection are described.

[发布机构] Gdask University of Technology, Faculty of Electronics, Telecommunications and Informatics, Department of Metrology and Optoelectronics, Narutowicza 11/12, Gdask; 80-233, Poland^1

[关键词] Blood glucose monitoring;Computing devices;Correction techniques;Detection technology;Fiber optical probes;Glucose concentration;Noninvasive measurements;Raman spectrometers