Bioelectrical Impedance and The Frequency Dependent Current Conduction Through Biological Tissues: A Short Review

[摘要] Biological tissues are developed with biological cells which exhibit complex electrical impedance called electrical bioimpedance. Under an alternating electrical excitation the bioimpedance varies with the tissue anatomy, composition and the signal frequency. The current penetration and conduction paths vary with frequency of the applied signal. Bioimpedance spectroscopy is used to study the frequency response of the electrical impedance of biological materials noninvasively. In bioimpedance spectroscopy, a low amplitude electrical signal is injected to the tissue sample or body parts to characterization the sample in terms of its bioimpedance. The electrical current conduction phenomena, which is highly influenced by the tissue impedance and the signal frequency, is an important phenomena which should be studied to understand the bioimpedance techniques like bioelectrical impedance analysis (BIA), EIS, or else. In this paper the origin of bioelectrical impedance and current conduction phenomena has been reviewed to present a brief summary of bioelectrical impedance and the frequency dependent current conduction through biological tissues. Simulation studies are conducted with alternation current injection through a two dimensional model of biological tissues containing finite number of biological cells suspended in extracellular fluid. The paper demonstrates the simulation of alternating current conduction through biological tissues conducted by COMSOL Multiphysics. Simulation studies also show the frequency response of the tissue impedance for different tissue compositions.

[发布机构] Department of Instrumentation and Applied Physics, Indian Institute of Science (IISc), Bangalore; 560012, India^1;Department of Medical Imaging, University of Arizona (UofA), Tucson; AZ; 85724, United States^2

[关键词] Bio-Impedance spectroscopies;Bio-impedance technique;Bioelectrical impedance;Bioelectrical impedance analysis;Electrical bio-impedance;Electrical excitation;Frequency dependent current;Two dimensional model