Bilayer tablets of Paliperidone for Extended release osmotic drug delivery

[摘要] The purpose of this study is to develop and optimize the formulation of paliperidone bilayer tablet core and coating which should meet in vitro performance of trilayered Innovator sample Invega. Optimization of core formulations prepared by different ratio of polyox grades and optimization of coating of (i) sub-coating build-up with hydroxy ethyl cellulose (HEC) and (ii).enteric coating build-up with cellulose acetate (CA). Some important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated. The optimization of formulation and process was conducted by comparing different in vitro release behaviours of Paliperidone. In vitro dissolution studies of Innovator sample (Invega) with formulations of different release rate which ever close release pattern during the whole 24 h test is finalized.

[发布机构] Chemistry Department, SAS, VIT University, Vellore, Tamil Nadu; 632014, India^1

[效力级别] 工业技术

[关键词] Cellulose acetates;Coating solution;Enteric-coating;Ethyl cellulose;Extended release;In-vitro dissolution;Osmotic drug delivery;Release pattern