Synthesis and biological evaluation of some novel substituted 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamides
[摘要] A novel class of substituted 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide has been synthesized by simple, modified Hantzsch condensation reaction using N-arylacetoacetamides, aryl aldehydes and ammonia. Characterisation of the newly synthesized compounds was carried out by spectral analysis (IR, 1H NMR and Mass Spectroscopy). Antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans and antiulcer activity by aspirin induced and pyloric ligation ulcer model was studied. Results revealed that most of the compounds exhibit significant antimicrobial activity along with antiulcer activity. The compound 6i 4-dimethylamino phenyl group at 4thposition of 1,4-dihydropyridine had shown 65% ulcer protection at 10 mg/kg administration in male albino rats.
[发布日期] [发布机构] Department of Chemistry, VIT University, Vellore, Tamil Nadu; 632 014, India^1;Chemists College of Pharmaceutical Sciences and Research, Varikoli P O, Puthencruz, Kerala; 682 308, India^2;Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudy, Madurai; 625 107, India^3;Department of Pharmaceutical Chemistry, St. James College of Pharmaceutical Sciences, Chalakudy, Kerala; 680 307, India^4
[效力级别] 工业技术 [学科分类]
[关键词] 1 ,4-dihydropyridine;Anti-microbial activity;Anti-ulcer activities;Biological evaluation;Candida albicans;Mass spectroscopy;Pyloric ligations;Staphylococcus aureus [时效性]
