Synthesis of Novel Isochromen-1-one analogues of Etodolac

[摘要] In the present work, anti-inflammatory drug based novel isochromen-1-one, their thio and N-methylated analogues were synthesized from the etodolac bulk drug, 1. All the synthesized compounds were purified and successfully characterized by FT-IR,1H NMR,13C NMR and Mass spectroscopy. All the derivatives procured are with remarkable yields from 67-72%.

[发布机构] Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu; 632014, India^1

[效力级别] 工业技术

[关键词] 13C NMR;Anti-inflammatory drugs;Bulk drugs;Etodolac;Mass spectroscopy