Synthesis and Biological Activity of Azine Heterocycle Functionalized Quaternary Phosphonium salts

[摘要] Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal activity against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). Quinoline functionalized phosphonium has shown more antibacterial activity than pyrazine and quinoxaline.

[发布机构] Department of Chemistry, School of Advanced Sciences, VIT University, Vellore Tamil Nadu, India^1

[效力级别] 工业技术

[关键词] Anti-bacterial activity;Bactericidal activity;Gram-negative bacteria;Gram-positive bacterium;Klebsiella pneumoniae;Phosphonium salts;Staphylococcus aureus;Structural characterization