Design of Genetic Circuit for Monitoring and Treatment of Stroke

[摘要] Nowadays, stroke has become a huge threat to human health and has become the first one of the top ten causes for death in the world. In the detection and diagnosis of stroke, optimization of markers and design of corresponding gene circuits have important research and application prospects. In this paper, we propose an improved Support Vector Model (SVM) by combining Principle Component Analysis (PCA) with Mutual Information (MI) to effectively figure out the proper stroke biomarkers with high specificity and sensitivity. The design of the single-index detection circuits is implemented. And the input circuit and critical circuit of the Single-index Detection Circuit are analysed. On the basis of the single-index detection circuit, a multi-marker detection circuit is built using OR GATE and AND GATE logic circuits to achieve the detection of multi-markers.

[发布机构] School of Electronic and Information Engineering, Beihang University, Beijing; 100191, China^1

[效力级别] 无线电电子学 [学科分类] 计算机科学（综合）

[关键词] Critical circuits;Detection and diagnosis;Detection circuits;Genetic circuits;Marker detections;Mutual informations;Principle component analysis;Research and application