Physico-chemical separation process of nanoparticles in cosmetic formulations

[摘要] Understanding the world of nanoparticles, especially their interactions with the environment, begins with their correct detection and successive quantification. To achieve this purpose, one needs to perform correctly developed standard operating procedures (SOPs). Furthermore, the study of nanoparticles frequently requires their characterisation in complex media (e.g. in cosmetic formulations). In this study, a set of sample preparation procedures for the detection and extraction of NMs in emulsion-based formulations is proposed and their performance for model and real-life products is discussed. A separation or extraction of lipid phases is achieved by means of organic solvents. The polarity of the lipid phases is decisive for selecting an optimum solvent. The use of the Hansen Solubility Parameters (HSP) may clearly support this decision.

[发布机构] Research Group Mechanical Process Engineering, Institute of Process Engineering and Environmental Technology, Technische Universitat Dresden, Münchner Platz 3, Dresden; D-01062, Germany^1

[效力级别] 医药卫生

[关键词] Complex media;Cosmetic formulations;Hansen solubility parameters;Physico-chemicals;Sample preparation procedure;Standard operating procedures