The quenching effect in PRESAGE? by a proton beam: Investigation of formulation dependence

[摘要] The radiochromic dosimeter PRESAGE® has shown potential in conventional radiotherapies, but it suffers from dose under-responding, or signal quenching, in proton therapy as a result of dependence on variations in the linear energy transfer (LET). Early investigations have shown the under-response is affected by the chemical concentration of the active components, but as yet this relationship has not been comprehensively measured. This study investigated the impact of PRESAGE® formulation changes on signal quenching to determine the magnitude by which the quenching can be minimized.

[发布机构] Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston; TX; 77030, United States^1;University of Texas at Houston Graduate, School of Biomedical Sciences, Houston; TX; 77030, United States^2

[关键词] Active components;Chemical concentrations;Linear energy transfer;Proton therapy;Quenching effect