Tetrazolium salt monomers for gel dosimetry I: Principles

[摘要] Tetrazolium salts (TS) have been previously used for radiochromic dosimetry in solutions, films and three dimensional (3D) gelatine-based gels. However, widespread application for 3D dosimetry has not been achieved due to the required high concentrations and associated high costs of the TS dimer used in prior research. Through careful selection of TS monomer, sensitivity-enhancing additives and inert gel forming material, we report the preparation of a non-diffusing, chemically stable, 3D dosimeter with linear sensitivity between 0 and 80 Gy with submillimolar requirements for the active TS.

[发布机构] Department of Chemical and Biochemical Engineering, University of Western Ontario, London; ON; N5A 5B9, Canada^1;Modus Medical Devices Inc., 1570 N Routledge Park, London; ON; N6H 5L6, Canada^2;Biomedical Engineering Program, University of Western Ontario, London; ON; N6A 5B9, Canada^3

[关键词] 3d dosimeters;Gel dosimetry;Gel-forming materials;High costs;Linear sensitivity;Threedimensional (3-d)