Preparation and Characterization of Porous Poly (Vinyl Alcohol) (PVA) Hydrogel filled with Multifunctional Extracellular Components for Cartilage Regeneration

[摘要] Articular cartilage has a very limited self-repair ability due to its avascular structure.Cartilage defect causes several dysfunctions as decreased load resistance and lubrication during joint motions.Poly (vinyl alcohol) (PVA) hydrogel has been proposed as a non-degradable and biocompatible FDA-approved synthetic biomaterial.In this study, we fabricated PVA sponge filled with bioactive components and applied them for cartilage repair application.Photopolymerizing chondroitin sulfates (CS) or hyaluronic acid (HA) were injected into macroporous PVA sponge with chondrocytes to fill the pores.Our study showed that CS enhanced the extracellular matrix accumulation and chondrocyte-related gene expressions.Moreover, HA increased the expression of genes involved in the lubrication process of articular cartilage.Overall this study demonstrates durable PVA hydrogel incorporated with bioactive components can be further utilized for functional cartilage tissue engineering.

[发布机构] University:서울대학교 대학원

[效力级别] Hydrogel

[关键词] PVA (Poly Vinyl Alcohol);Hydrogel;Hyaluronic Acid;Chondroitin Sulfate;Chondrocyte;Cartilage Tissue Engineering;660