Problem behaviours in tuberous sclerosis complex

[摘要] The profile of behaviours in tuberous sclerosis complex (TSC, e.g. self-injury, physical aggression, repetitive behaviours) is not well defined in relation to developmental change over time. This research aimed to investigate the profile of behaviours in children with TSC across specific developmental stages (e.g. early childhood, adolescence) and also compared to typical development. Based on informant-report measures of behaviour both younger (1-4 years) and older children with TSC (5-11 years) evidenced higher ratings of stereotyped behaviour and impulsivity than age-matched typically developing groups. A 20-month follow-up study with this younger TSC cohort elucidated a clear distinction between ‘lower-order’ and ‘higher-order’ repetitive behaviours according to level of ability/adaptive functioning and a particular emphasis on executive functioning deficits in relation to externalising behaviours (e.g. self-injury) and ASD/ADHD characteristics (e.g. insistence on sameness, impulsivity). Exploring a broader range of behaviours and contextual issues in children and adolescents with TSC revealed: 1) externalising behaviour frequency was a strong predictor of caregiver anxiety and 2) high levels of caregiver concern relating to temper outbursts. Overall, this research significantly contributes to our understanding of risk factors/risk markers for behaviours and provides empirical support for a brain-cognition-behaviour pathway in TSC.

[发布机构] University:University of Birmingham;Department:School of Psychology

[关键词] B Philosophy. Psychology. Religion;BF Psychology