The synthesis and characterisation of novel supramolecular structures and their binding to DNA

[摘要] The aim of this thesis was to synthesise and characterise the DNA binding of novel structures based on a supramolecular cylinder. These structures are designed to retain the three way junction binding properties of the parent cylinder, while making modifications which have the potential to change DNA binding properties such as binding capacity, selectivity and control. The first chapter provides and introduction to non-canonical DNA structures and the ligands which have been developed to bind them. In chapter 2, the synthesis of new supramolecular cylinders, a trinuclear helicate and an asymmetric helicate, is investigated. A method for post assembly modification of a cylinder analogue is developed in chapter 3, which is then used to synthesise the first rotaxane from a supramolecular helicate via the capping mechanism. These structures are analysed by mass spectrometry and NMR. Finally, the DNA binding of a cylinder analogue and the rotaxane is investigated using UV Visible spectroscopy, circular dichroism and linear dichroism in chapter 4.

[发布机构] University:University of Birmingham;Department:School of Chemistry

[关键词] Q Science;QD Chemistry