Tract-based Spatial Statistics and fMRI Analysis in Patients with Small Cell Lung Cancer before Prophylactic Cranial Irradiation

[摘要] Prophylactic cranial irradiation (PCI) is known to increase life expectancy to a significant degree in Small Cell Lung Cancer (SCLC) patients. The overall scope of this research is to investigate changes in structural and functional connectivity between SCLC patients and controls before and after PCI treatment. In the current study specifically we use diffusion tensor imaging (DTI) and functional Magnetic Resonance (fMRI) to identify potential alterations in white matter structure and brain function respectively, in SCLC patients before PCI compared to healthy participants. The results in DTI analysis have showed lower fractional anisotropy (FA) and higher eigenvalues in white matter regions in the patient group. Similarly, in fMRI analysis a lower level of activation in the primary somatosensory cortex was reported. The results presented herein are subject to further investigation with larger patient and control groups.

[发布机构] National Technical University, Athens School of Electrical and Computer Engineering Microwave, Fiber Optics Laboratory, Greece^1;Research Centre of Radiology and Imaging, Evgenidion General Hospital, Greece^2;Department of Medical Instrumentation Technology, Technological Educational Institution of Athens, Greece^3;National and Kapodistrian University of Athens, Division of Radiology- Radiotherapy II, Greece^4

[效力级别] 医药卫生 [学科分类] 卫生学

[关键词] Fractional Anisotropy;Functional connectivity;Higher eigenvalues;Primary somatosensory cortex;Prophylactic cranial irradiations;Small cell lung cancers;Small-cell lung cancer;Spatial statistics