Polycrystalline para-terphenyl scintillator adopted in a β? detecting probe for radio-guided surgery

[摘要] A radio-guided surgery technique exploiting β-emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharmaceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting β-radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical fibres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.

[发布机构] Dip. Fisica, Sapienza Univ. di Roma, Rome, Italy^1;INFN Sezione di Roma, Rome, Italy^2;Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Rome, Italy^3;Laboratori Nazionali di Frascati dell'Infn, Frascati (RM), Italy^4;Museo Storico della Fisica e Centro Studi e Ricerche e. Fermi, Rome, Italy^5;Dipartimento di Fisica, Università Roma Tre, Rome, Italy^6;Center for Life Nano Science at Sapienza, Istituto Italiano di Tecnologia, Rome, Italy^7

[效力级别] 工业技术 [学科分类] 工业工程学

[关键词] Activity ratios;Intra-operative;Organic scintillator;Photo multiplier tube;Polycrystalline;Readout Electronics;Remote monitoring;Scintillation light