Modelling irradiation by EM waves of multifunctionalized iron oxide nanoparticles and subsequent drug release

[摘要] Thermal transport in the environment close to the periphery of the nanoparticle, from a few angstroms to less than a nanometer scale, is becoming increasingly important with the advent of several biomedical applications of multifunctional magnetic nanoparticles, including drug delivery, magnetic resonance imaging, and hyperthermia therapy. We present a multiscale and multiphysics model of the irradiation by electromagnetic waves of radiofrequency of iron oxide nanoparticles functionalized by drug-releasing polymers used as new multifunctional therapeutic compounds against tumors. We compute ab initio the thermal conductivity of the polymer chains as a function of the length, model the unfolding of the polymer after heat transfer from the nanoparticle by molecular mechanics, and develop a multiscale thermodynamic and heat transfer model including the surrounding medium (water) in order to model the drug release.

[发布机构] Université du Maine (Le Mans), Institut des Molécules et Matériaux du Mans, France^1

[效力级别] 数学

[关键词] Biomedical applications;Heat transfer model;Iron oxide nanoparticle;Magnetic nano-particles;Multi-functionalized;Multi-physics modeling;Radio frequencies;Therapeutic compounds