Caracterização biológica de clones das cepas Y, CL e MR de Trypanosoma cruzi em camundongos C3H isogênicos

[摘要] Ten clones of Trypanosoma cruzi isolated from Y, CL and MR strains were studied. The infectivity of culture forms, parasitemia pattern, polymorphism and mortality were studied in C3H inbred mice. Significant intra-group differences among Y and CL clones were found. MR clones showed higher homogeneity. These data indicate that T. cruzi strains can show different degrees of heterogeneity. It is suggested that conditions used to maintain T. cruzi strains may resuly in a selective advantage for some subpopulations (clones) after many years laboratory maintenance.

[关键词] clone;heterogeneity;Trypanosoma cruzi;clone;heterogeneidade;Trypanosoma cruzi