Feasibility of PET/CT 3-D dosimetry for proton-activated PRESAGE? dosimeters

[摘要] A feasibility study is considered using PRESAGE® dosimeters as a direct dosimetry comparison tool to correlate proton activation to dose in a clinical beam. Proton activation measured by PET/CT has been studied as a future tool method for in vivo dosimetry. PRESAGE® is a 3D offline dosimeter that has a material composition giving it a longer activation decay time than similar dosimeters allowing easier measurements. In this study, the PRESAGE® positron emissions were measured by PET and directly compared to dose measurements made by optical-CT to make spatial comparisons of dose and proton activation. Profiles along the central axis of the beam found a shift in the distal-80% resulting in the proton activation profile being 1 cm shallower than the dose profile. Cross beam profiles demonstrated little discrepancy between long (3 hour) and short (30 minute) PET scan times.

[发布机构] Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston; TX; 77030, United States^1;University of Texas at Houston, Graduate School of Biomedical Sciences, Houston; TX; 77030, United States^2;Rider University, Lawerenceville; NJ, United States^3;Heuris Pharma, LLC, 412 Sunset Rd., Skillman; NJ; 08558, United States^4

[关键词] Central axis;Cross beams;Dose measurement;Dose profile;Feasibility studies;Material compositions;Positron emission;Spatial comparison