The quenching effect in PRESAGE? dosimetry of proton beams: Is an empirical correction feasible?

[摘要] Chemical dosimeters, including PRESAGE® as used in optical CT, exhibit significant quenching effects in response to proton irradiation and this may limit their widespread uptake. This study performs careful measurements of the observed quenching of a recently developed variant of PRESAGE® in a 60 MeV proton beam and uses them to attempt an empirical correction of a simple superposition of two unmodulated beams.

[发布机构] CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom^1;University of Surrey, Guildford, United Kingdom^2;Institute of Medical Physics, School of Physics, University of Sydney, NSW; 2006, Australia^3;Department of Chemistry and Biology, Rider University, Lawrenceville; NJ, United States^4;Heuris Pharma, LLC, 412 Sunset Rd., Skillman; NJ; 08558, United States^5;Douglas Cyclotron, Clatterbridge Centre for Oncology, Wirral, United Kingdom^6

[关键词] Measurements of;Optical CT;Quenching effect