Electrospun materials for affinity-based engineering and drug delivery

[摘要] Electrospinning is a process which can quickly and cheaply create materials of high surface to volume and aspect ratios from many materials, however in application toward drug delivery this can be a strong disadvantage as well. Diffusion of drug is proportional to the thickness of that device. In moving from macro to micro to nano-sized electrospun materials drug release rates change to profiles that are too fast to be therapeutically beneficial. In this work we use molecular interactions to further control the rate of release beyond that capable of diffusion alone. To do this we create materials with molecular pockets, which can "hold" therapeutic drugs through a reversible interaction such as a host/guest complexation. Through these complexes we show we are able to impact delivery of drug from electrospun materials, and also apply them in tissue engineering for the reversible presentation of biomolecules on a fiber surface.

[发布机构] Department of Biomedical Engineering, Case Western Reserve University, Cleveland; OH, United States^1

[效力级别] 数学

[关键词] Drug-release rate;Electrospun materials;Fiber surface;Nano sized;Reversible interactions;Therapeutic drugs