Single cell array impedance analysis in a microfluidic device

[摘要] Impedance analysis of single cells is presented in this paper. Following the separation of a target cell type by dielectrophoresis in our previous work, this paper focuses on capturing the cells as a single array and performing impedance analysis to point out the signature difference between each cell type. Lab-on-a-chip devices having a titanium interdigitated electrode layer on a glass substrate and a PDMS microchannel are fabricated to capture each cell in a single form and perform impedance analysis. HCT116 (homosapiens colon colorectal carcin) and HEK293 (human embryonic kidney) cells are used in our experiments.

[发布机构] Department of Nanoscience and Nanotechnology, Istanbul Technical University, Istanbul, Turkey^1;Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, Turkey^2

[效力级别] 力学 [学科分类] 力学，机械学

[关键词] Glass substrates;Human embryonic kidneys;Impedance analysis;Inter-digitated electrodes;Lab-on-a-chip devices;Micro-fluidic devices;PDMS microchannels;Single cells