Spectrophotometric Determination of Methimazole in Pharmaceutical Sample by Fe(II)-2,2'-Bipyridyl System

[摘要] By controlling pH=5.0, Fe(III) could be reduced to Fe(II) by hydrosulfuryl (-SH) in methimazole molecule, then Fe(II) reacts with 2,2′-bipyridyl to form the orange red complex which the maximum absorption is at 522nm. The content of methimazole can be measured by measuring the amount of the complex of Fe(II)-2,2′-bipyridyl. A accurate fast spectrophotometric method for the determination the content of methimazole had been established. A good linear relationship was obtained between A and the concentration of methimazole in the range of 0.0004000-0.004000mg/mL, the equation of the linear regression was A=0.02707+136.29C(mg/mL), with a linear correlation coefficient was 0.9994. This proposed method had been successfully applied to determinate of methimazole in real pharmaceutical.

[发布机构] College of Chemistry and Environment, Jiaying University, Meizhou GUANGDONG; 514015, China^1

[关键词] Bipyridyl;Linear correlation coefficient;Linear relationships;Methimazole;Orange-red;Spectro-photometric method;Spectrophotometric determination