Anti-hyperglycemic effect and glucose tolerance of guajava (Psidium guajava L.) leaf ethanol extract in diabetic rats

[摘要] Traditionally guava (Psidium guajava L) leaf is used for treatment of various ailments like diarrhea, wounds, rheumatism, anti-allergy, ant-spasmodic, etc, as folk medicine. The aim of this research is to know the effect of hypoglycemia and glucose tolerance of ethanol extract of guava leaf against male white rat. The guajava leaf was obtained from Balitro Bogor. Preparation of guajava leaf extract was done by cold maceration extraction technique using ethanol 70%. Male albino rats were made into diabetics using the alloxan method. Rats were divided into 6 groups, as a comparative drug for anti-hyperglycemic used glibenclamid and as a comparative drug for glucose tolerance used acarbose. The result of blood glucometer test showed that ethanol extract 70% of guajava leaf had effect as anti-hyperglycemic and glucose tolerance with no significant difference with glibenclamid drug as anti-hyperglycemic and acarbose as glucose tolerance drug.

[发布机构] Department of Pharmacy, Faculty of Medicne and Health Sciences, State Islamic University, Syarif Hidayatullah, Jakarta, Indonesia^1;Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia^2

[效力级别] 化学 [学科分类] 生物科学（综合）

[关键词] Anti allergies;Diabetic rats;Ethanol extract;Extraction techniques;Glucose tolerance;Leaf extracts;Psidium guajava;Psidium guajava l