Araguspongine: an indole alkaloid as panc-1 cell inhibitory adapted to nutrient starvation from Indonesian's marine sponge spongionellapulchella

[摘要] Isolation of active metabolite from Indonesian's Marine Sponge Spongionellapulchella has been conducted on July 2018. Active compound isolated based on bioassay-guided separation with several steps of chromatography. The rate of viability shows that IC50 = 0.2 μg / mL against PANC-1 cell. The active compound know as C28H51N2O2 determined by LCMS-ESI with molecular weight [M+H]+447.3951m/z. Based on the FTIR spectrum shows that the active metabolite has functional groups at 3435.56 cm1 as N-H secondary amines, 2853.39 cm1 as C-H methyl, 2769.64 cm1 as C-H methylene and the fingerprint region of amine at 1637.27 cm1 as C-N imine. The active compound which knows as araguspongine, an indole alkaloid shows potential activity against PANC-1 cell.

[发布机构] Department of Marine Science, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh; 23111, Indonesia^1;Marine Chemistry Laboratory, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh; 23111, Indonesia^2;Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa; 903-0213, Japan^3

[效力级别] 农业科学

[关键词] Active compounds;Active metabolites;FT-IR spectrum;Indole alkaloids;Marine sponge;Nutrient-starvation;Potential activities;Secondary amines