Inhibitory of PANC-1 produced by Indonesian's Marine Sponge Endectyon delaubenfelsi Adapted to Nutrient Starvation

[摘要] The bioactivity of Indonesian Marine Sponge Endectyon delaubenfelsi has been conducted on July 2018. The active metabolite based on bioassay guided-separation with several steps of chromatography. The FTIR spectrum shows that the active metabolite has N-H amine functional groups at 3434.6 cm-1 C-H methyl was detected at 3090.46 cm-1, and the fingerprint region at 1637.27 cm-1 as C-N imine. Based on the FTIR data shows indicate that the active compound as alkaloid. Metabolite active has activity IC50 = 0.2 ug / mL indicates that the active compound from of Endectyon delaubenfelsi has potential activity as the new model to the drug discovery against PANC-1 cell.

[发布机构] Department of Marine Science, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh; 23111, Indonesia^1;Marine Chemistry Laboratory, Faculty of Marine and Fisheries, Syiah Kuala University, Banda Aceh; 23111, Indonesia^2;Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa; 903-0213, Japan^3

[效力级别] 农业科学

[关键词] Active compounds;Active metabolites;Amine functional groups;Drug discovery;FT-IR spectrum;Marine sponge;Nutrient-starvation;Potential activities