Antibacterial and Antifungal Effect of 405 nm Monochromatic Laser on Endodontopathogenic Microorganisms

[摘要] The purpose of this study is to evaluate the usefulness of 405 nm monochromatic laser irradiation as an alternative management for prevention and/or treatment of endodontic infections. A monochromatic laser-emitting device equipped with a 405-nm laser diode was developed. Using this device, the effect of 405 nm laser irradiation on the growth ofPorphyromonas gingivalis, Prevotella intermedia, Enterococcus faecalis, andCandida albicans, which are microorganisms associated with persistent endodontic infections, was evaluated by viable colony counting. As a result, the irradiation with a 405 nm laser had a significant bactericidal/fungicidal effect onP. gingivalis, P. intermedia, andC. albicans, whereas the growth ofE. faecaliswas not affected by the irradiation. The inhibition rate inP. gingivalisandP. intermediawas ~60% and ~80%, respectively, following irradiation at 0.2 W for 300 sec. The inhibition rate inC. albicanswas ~90% following irradiation at 0.2 W for 1200 sec. These results indicate that 405 nm monochromatic laser irradiation exerts a bactericidal/fungicidal effect on these microorganisms. The present study clearly demonstrates that 405 nm laser irradiation is a promising alternative management strategy for prevention and/or treatment of endodontic infections.

[学科分类] 物理化学和理论化学