Photoinduced Aromatization of Asymmetrically Substituted 1,4-Dihydropyridine Derivative Drug Cilnidipine

[摘要] The antihypertensive drug Cilnidipine (1) is photolabile under UV-A light. Irradiation of a chloroform solution of Cilnidipine under aerobic and anaerobic conditionsproduces a common photoproduct which was isolated as 2-methoxyethyl-3-phenyl-2-propenyl pyridine dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (2). The formation of products was explained by photochemical aromatization of Cilnidipine.

[学科分类] 物理化学和理论化学