Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”

[摘要] Easy, quantitative, and one-pot introduction of eightβ-lactoside-modules onto a porphyrin-core was achieved throughCu+-catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals andβ-lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.

[学科分类] 有机化学