Molecular Abnormalities in Ovarian Cancer Subtypes Other than High-Grade Serous Carcinoma

[摘要] Ovarian cancer is the fifth leading cause of cancer death in women in NorthAmerica, and approximately two-thirds of cases of ovarian cancer are of high-gradeserous type. The remaining cases are comprised of a mix of differenttumor types (e.g., endometrioid, clear cell, mucinous, etc.), with no single tumortype accounting for more than 10% of ovarian cancer cases. These tumor typescan be reproducibly diagnosed, and each features distinct underlying molecularevents during oncogenesis, with a characteristic natural history and responserate to conventional cytotoxic chemotherapy. In this review the molecularabnormalities present in the more common non-high-grade serous subtypes ofovarian cancer will be presented. Development of targeted therapies for these tumor types will require understanding of the genetic basis of each tumor type, and may lead to subtype-specific therapy.

[学科分类] 肿瘤学