Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

[摘要] Background/Aims.Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients.Methods.ELISA was used to analyze MCP-1 serum levels in PDA (n=62) and intraductal papillary mucinous neoplasms (IPMN) (n=27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters.Results.Log MCP-1 values were significantly (P<0.05) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age.Conclusion.MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.

[学科分类] 肿瘤学