Small-Cell Lung Cancer: 8 Years Experience of a Single Multidisciplinary Team

[摘要] Aims. We have audited the changes in treatmentpractice for small-cell lung cancer (SCLC) presented to a singlemultidisciplinary team (MDT) at Doncaster and Bassetlaw Hospitalsbetween January 1998 and December 2005.Materials andMethods. The MDT database was used to identify allpatients with SCLC. Anonymised demographic, treatment, and outcomedetails were extracted from the database supplemented by patientrecords.Results. 235 patients were identified.112 (48%) had limited disease at presentation. Chemotherapywas the initial treatment for 195 patients, 77% of whom had adocumented radiological response with a complete response in24%. Chemotherapy regimes evolved during the study period withthe increasing use of platinum-based chemotherapy. Anthracycline-basedchemotherapy was most used before 2004 and was given to 57% ofall patients. 42% received consolidation thoracic radiotherapyand 24% prophylactic cranial irradiation. The median and2-year survival were 8 months and 18%, respectively, forpatients with limited disease and 5 months and 5%, respectively,for extensive disease.Conclusion. We havedocumented changes in treatment practice and service delivery ofSCLC over the 8 years during which the MDT has been operating. However,there has not achieve any significant improvement in outcome for thepopulation of patients with SCLC.

[学科分类] 肿瘤学