Retrospective Study of Selective Submandibular NeckDissection versus Radical Neck Dissection for N0 or N1 Necks inLevel I Patients with Oral Squamous Cell Carcinoma

[摘要] Objective. To evaluate the efficacy of selective submandibular neck dissection (SMND) in patients with oral squamous cell carcinoma (OSCC) with or without nodal metastasis.Patients. From a total of 384 patients with untreated OSCC who underwent radical excision, we identified 229 with clinically N0 necks and 68 with clinically N1 necks in level I.Main Outcome Measures. The Kaplan-Meier 5-year regional control and 5-year disease specific survival (DSS) were compared for SMND, radical neck dissection (RND), and modified radical neck dissection (MRND).Results. In clinically node-negative necks, the regional control rates were 85.2% with SMND and 83.3% with MRND (P=0.89), and 5-year DSS rates were 86.5% and 87.0%, respectively, (P=0.94). In clinically N1 necks, the regional control rates were 81.3% with SMND and 83.0% with RND (P=0.72), and the DSS rates were 81.3% and 80.0%, respectively, (P=0.94). Type of neck dissection was not significantly associated with regional control or DSS on either univariate or multivariate analysis using Cox’s proportional hazard model.Conclusions. SMND can be effectively applied in elective and therapeutic management to patients with OSCC that are clinically assessed as N0 or N1 to level I of the neck.

[学科分类] 肿瘤学