N-Acetyltransferase 1 (NAT1) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population

[摘要] In Lebanon, bladder cancer is the second most incident cancer among men. This study investigates a possible association between N-acetyltransferase 1 (NAT1) genotype, a drug-metabolizing enzyme coding gene, and bladder cancer in Lebanese men. A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut. Cases were randomly selected from patients diagnosed in the period of 2002–2008. Controls were conveniently identified and selected from the same settings. Data was collected using interview questionnaire and blood analysis.NAT1genotypes were determined by PCR-RFLP. Statistical analysis revolved around univariate, bivariate, and multivariate logistic regression models, along with checks for effect modification. Results showedNAT1∗14Aallele, smoking, occupational exposure to combustion fumes, and prostate-related symptoms, to be risk factors for bladder cancer. The odds of carrying at least oneNAT1∗14Aallele are 7 times higher in cases compared to controls (OR=7.86, 95% CI: 1.53–40.39). A gene-environment interaction was identified forNAT1∗14Aallele with occupational exposure to combustion fumes. Among carriers ofNAT1∗14Aallele, the odds of bladder cancer dropped to 2.03 from 3.72. Our study suggestsNAT1∗14Aallele as a possible biomarker for bladder cancer. Further research is recommended to confirm this association.

[学科分类] 肿瘤学