Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients

[摘要] Fatty acid metabolism is altered in colorectal cancer (CRC). We aimed to investigate incorporation of dietaryn-6 andn-3 polyunsaturated fatty acids (PUFAs) into plasma phospholipids (PLs), tumour tissue, and normal mucosa in young CRC patients. We also aimed to study differences in PUFA composition between tumour and normal mucosa, and PUFA status associated with cancer stage. Sixty-five CRC patients younger than 55 years were included in a multicenter study. We assessed dietary fatty acid composition by food-frequency questionnaire. Fatty acid composition in plasma PL (n=65) and tumour and normal colonic biopsies (n=32) were analysed by gas chromatography. We observed a significant correlation for docosahexaenoic acid (DHA) between dietary intake and concentration in plasma PL (weight%) (r=0.42;P=0.001), but not for anyn-6 PUFA. Tissue concentrations of arachidonic acid, eicosapentaenoic acid, and DHA (weight%) were 1.7–2.5 times higher in tumour than normal mucosa (P≤0.001). Concentrations ofn-3 andn-6 PUFA in plasma PL and tissues were not related to Duke's stage, although patients with more severe cancer stage reported higher intake ofn-3 PUFA. In conclusion, we found accumulation of the long-chainedn-3 andn-6 PUFA in tumour tissue in young CRC patients.

[学科分类] 肿瘤学