The Human Vaginal Bacterial Biota and Bacterial Vaginosis

[摘要] The bacterial biota of the human vagina can have a profound impact on the health of women and their neonates. Changes in the vaginal microbiota have been associated with several adverse health outcomes including premature birth, pelvic inflammatory disease, and acquisition of HIV infection. Cultivation-independent molecular methods have provided new insights regarding bacterial diversity in this important niche, particularly in women with the common condition bacterial vaginosis (BV). PCR methods have shown that women with BV have complex communities of vaginal bacteria that include many fastidious species, particularly from the phyla Bacteroidetes and Actinobacteria. Healthy women are mostly colonized with lactobacilli such asLactobacillus crispatus,Lactobacillus jensenii, andLactobacillus iners, though a variety of other bacteria may be present. The microbiology of BV is heterogeneous. The presence ofGardnerella vaginalisandAtopobium vaginaecoating the vaginal epithelium in some subjects with BV suggests that biofilms may contribute to this condition.

[学科分类] 传染病学