Larvicidal Activity againstAedes aegyptiand Molluscicidal Activity againstBiomphalaria glabrataof Brazilian Marine Algae

[摘要] This study investigated the biological activities of five benthic marine algae collected from Northeastern Region of Brazil. The tested activities included larvicidal activity againstAedes aegypti, molluscicidal activity againstBiomphalaria glabrata,and toxicity againstArtemia salina. Extracts ofUlva lactuca(Chlorophyta),Padina gymnospora, Sargassum vulgare(Phaeophyta),Hypnea musciformis,andDigenea simplex(Rhodophyta) were prepared using different solvents of increasing polarity, including dichloromethane, methanol, ethanol, and water. Of the extracts screened, the dichloromethane extracts ofH. musciformisandP. gymnosporaexhibited the highest activities and were subjected to bioassay-guided fractionation in hexane and chloroform. The chloroform fractions of theP. gymnosporaandH. musciformisextracts showed molluscicidal activity at values below 40 μg·mL−1(11.1460 μg·mL−1and 25.8689 μg·mL−1, resp.), and the chloroform and hexane fractions ofP. gymnosporashowed larvicidal activity at values below 40 μg·mL−1(29.018 μg·mL−1and 17.230 μg·mL−1, resp.). The crude extracts were not toxic toA. salina, whereas the chloroform and hexane fractions ofP. gymnospora(788.277 μg·mL−1and 706.990 μg·mL−1) showed moderate toxicity, indicating that the toxic compounds present in these algae are nonpolar.

[学科分类] 神经科学