Maternal HLA-DR Homozygosity is not Associated with an Increased Risk of Fetal Loss

[摘要] An attractive but controversial hypothesis holds that HLA similarit\ between mother and offspring predisposes to early fetal loss, Against this background, Hoffet al. ( 1992) have reported a significant association between maternal HLA-DR homozygosity and fetal loss in a cohort of multigravid American women, To re-examine this finding independently, a similar investigation was carried out on a comparable group of British subjects. The HLA-DR data of 75 multigravid women were analysed: the proportion of women who had experienced fetal loss did not differ between HLA-DR homozygous and heterozygous subjects.

[学科分类] 生理学与病理学